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Article

Leucine-rich repeat transmembrane proteins are essential for maintenance of long-term potentiation.

Neuron - 7 Aug 2013

Soler-Llavina Gilberto J, Arstikaitis Pamela, Morishita Wade, Ahmad Mohiuddin, Südhof Thomas C, Malenka Robert C

Abstract excerpt

Leucine-rich repeat transmembrane proteins (LRRTMs) are synaptic cell adhesion molecules that trigger excitatory synapse assembly in cultured neurons and influence synaptic function in vivo, but their role in synaptic plasticity is unknown. shRNA-mediated knockdown (KD) of LRRTM1 and LRRTM2 in vivo in CA1 pyramidal neurons of newborn mice blocked long-term potentiation (LTP) in acute hippocampal slices. Molecular...

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Identifiers

PMID: 23931994
DOI: 10.1016/j.neuron.2013.06.007
PMCID: PMC3741667

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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