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Article

Differential Effects of Myeloid Cell PPARδ and IL-10 in Regulating Macrophage Recruitment, Phenotype, and Regeneration following Acute Muscle Injury.

Journal of immunology (Baltimore, Md. : 1950) - 15 Sept 2020

Welc Steven S, Wehling-Henricks Michelle, Antoun Jacqueline, Ha Tracey T, Tous Isabella, Tidball James G

Abstract excerpt

Changes in macrophage phenotype in injured muscle profoundly influence regeneration. In particular, the shift of macrophages from a proinflammatory (M1 biased) phenotype to a proregenerative (M2 biased) phenotype characterized by expression of CD206 and CD163 is essential for normal repair. According to the current canonical mechanism regulating for M1/M2 phenotype transition, signaling through PPARδ is necessary...

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Identifiers

PMID: 32817369
DOI: 10.4049/jimmunol.2000247
PMCID: PMC7484367

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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