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Article

Acid Sphingomyelinase Controls Early Phases of Skeletal Muscle Regeneration by Shaping the Macrophage Phenotype.

Cells - 5 Nov 2021

Roux-Biejat Paulina, Coazzoli Marco, Marrazzo Pasquale, Zecchini Silvia, Di Renzo Ilaria, Prata Cecilia, Napoli Alessandra, Moscheni Claudia, Giovarelli Matteo, Barbalace Maria Cristina, Catalani Elisabetta, Bassi Maria Teresa, De Palma Clara, Cervia Davide, Malaguti Marco, Hrelia Silvana, Clementi Emilio, Perrotta Cristiana

Abstract excerpt

Skeletal muscle regeneration is a complex process involving crosstalk between immune cells and myogenic precursor cells, i.e., satellite cells. In this scenario, macrophage recruitment in damaged muscles is a mandatory step for tissue repair since pro-inflammatory M1 macrophages promote the activation of satellite cells, stimulating their proliferation and then, after switching into anti-inflammatory M2...

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Identifiers

PMID: 34831250
DOI: 10.3390/cells10113028
PMCID: PMC8616363

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