Article
Myeloid HIFs are dispensable for resolution of inflammation during skeletal muscle regeneration.
Journal of immunology (Baltimore, Md. : 1950) - 1 Apr 2015
Gondin Julien, Théret Marine, Duhamel Guillaume, Pegan Katarina, Mathieu Jacques R R, Peyssonnaux Carole, Cuvellier Sylvain, Latroche Claire, Chazaud Bénédicte, Bendahan David, Mounier Rémi
Abstract excerpt
Besides their role in cellular responses to hypoxia, hypoxia-inducible factors (HIFs) are involved in innate immunity and also have anti-inflammatory (M2) functions, such as resolution of inflammation preceding healing. Whereas the first steps of the inflammatory response are associated with proinflammatory (M1) macrophages (MPs), resolution of inflammation is associated with anti-inflammatory MPs exhibiting an...
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