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A Transmembrane Domain and GxxxG Motifs within L2 Are Essential for Papillomavirus Infection

25 Oct 2012

Abstract excerpt

During cellular invasion, human papillomavirus type 16 (HPV16) must transfer its viral genome (vDNA) across the endosomal membrane prior to its accumulation at nuclear PML bodies for the establishment of infection. After cellular uptake, the capsid likely undergoes pH-dependent disassembly within the endo-/lysosomal compartment, thereby exposing hidden domains in L2 that facilitate membrane penetration of L2/vDNA...

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PMID: 23097431
DOI: 10.1128/jvi.01539-12

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