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Article

Conformational stability and membrane interaction of the full-length ectodomain of HIV-1 gp41: implication for mode of action.

Biochemistry - 14 Apr 2009

Lev Naama, Fridmann-Sirkis Yael, Blank Lior, Bitler Arkady, Epand Raquel F, Epand Richard M, Shai Yechiel

Abstract excerpt

Membrane fusion between the human immunodeficiency virus (HIV) and the target cell plasma membrane is correlated with conformational changes in the HIV gp41 glycoprotein, which include an early exposed conformation (prehairpin) and a late low energy six helix bundle (SHB) conformation also termed hairpin. Peptides resembling regions from the exposed prehairpin have been previously studied for their interaction...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 19206186
DOI: 10.1021/bi802243j

Genes

SHB
AFM

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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