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Article

SAHA enhances synaptic function and plasticity in vitro but has limited brain availability in vivo and does not impact cognition.

PloS one - 1 Jan 2013

Hanson Jesse E, La Hank, Plise Emile, Chen Yung-Hsiang, Ding Xiao, Hanania Taleen, Sabath Emily V, Alexandrov Vadim, Brunner Dani, Leahy Emer, Steiner Pascal, Liu Lichuan, Scearce-Levie Kimberly, Zhou Qiang

Abstract excerpt

Suberoylanilide hydroxamic acid (SAHA) is an inhibitor of histone deacetylases (HDACs) used for the treatment of cutaneous T cell lymphoma (CTCL) and under consideration for other indications. In vivo studies suggest reducing HDAC function can enhance synaptic function and memory, raising the pos...

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Identifiers

PMID: 23922875
DOI: 10.1371/journal.pone.0069964
PMCID: PMC3724849

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23922875-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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