Article
In vivo imaging reveals that pregabalin inhibits cortical spreading depression and propagation to subcortical brain structures.
Proceedings of the National Academy of Sciences of the United States of America - 28 Feb 2017
Cain Stuart M, Bohnet Barry, LeDue Jeffrey, Yung Andrew C, Garcia Esperanza, Tyson John R, Alles Sascha R A, Han Huili, van den Maagdenberg Arn M J M, Kozlowski Piotr, MacVicar Brian A, Snutch Terrance P
Abstract excerpt
Migraine is characterized by severe headaches that can be preceded by an aura likely caused by cortical spreading depression (SD). The antiepileptic pregabalin (Lyrica) shows clinical promise for migraine therapy, although its efficacy and mechanism of action are unclear. As detected by diffusion-weighted MRI (DW-MRI) in wild-type (WT) mice, the acute systemic administration of pregabalin increased the threshold...
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