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Article

Chronic GluN2B antagonism disrupts behavior in wild-type mice without protecting against synapse loss or memory impairment in Alzheimer's disease mouse models.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 11 Jun 2014

Hanson Jesse E, Meilandt William J, Gogineni Alvin, Reynen Paul, Herrington James, Weimer Robby M, Scearce-Levie Kimberly, Zhou Qiang

Abstract excerpt

Extensive evidence implicates GluN2B-containing NMDA receptors (GluN2B-NMDARs) in excitotoxic-insult-induced neurodegeneration and amyloid β (Aβ)-induced synaptic dysfunction. Therefore, inhibiting GluN2B-NMDARs would appear to be a potential therapeutic strategy to provide neuroprotection and im...

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Identifiers

PMID: 24920631
DOI: 10.1523/JNEUROSCI.5106-13.2014
PMCID: PMC6608240

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24920631-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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