Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Short-Chain HDAC Inhibitors Differentially Affect Vertebrate Development and Neuronal Chromatin

8 Nov 2010

Abstract excerpt

Carboxylic acids with known central nervous system and histone deacetylase (HDAC) inhibitory activities were converted to hydroxamic acids and tested using a suite of in vitro biochemical assays with recombinant HDAC isoforms, cell based assays in human cervical carcinoma Hela cells and primary cultures from mouse forebrain, and a whole animal (Xenopus laevis) developmental assay. Relative to the parent...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Histone Deacetylase Inhibitors Research
Share to Peptidase Inhibition and Analysis
Share to Protein Degradation and Inhibitors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 21874153
DOI: 10.1021/ml1001954

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Short-Chain HDAC Inhibitors Differentially Affect Vertebrate Development and Neuronal ChromatinPMID 21874153Read ↗

Histone Deacetylase Inhibitors: Development of Suberoylanilide Hydroxamic Acid (SAHA) for the Treatment of CancersSemantic proximity Read ↗

The HDAC6/8/10 inhibitor TH34 induces DNA damage-mediated cell death in human high-grade neuroblastoma cell linesSemantic proximity Read ↗

Inhibition of Histone Deacetylases: A Pharmacological Approach to the Treatment of Non-Cancer DisordersSemantic proximity Read ↗

The Pharmaceutical Potential of Histone Deacetylase InhibitorsSemantic proximity Read ↗

Selective inhibition of HDAC8 decreases neuroblastoma growth in vitro and in vivo and enhances retinoic acid-mediated differentiationSemantic proximity Read ↗

Unique functional roles for class I and class II histone deacetylases in central nervous system development and functionSemantic proximity Read ↗

Novel hydroxamic acid derivative induces apoptosis and constrains autophagy in leukemic cellsSemantic proximity Read ↗

Drug Discovery for Histone Deacetylase Inhibition: Past, Present and Future of Zinc-Binding GroupsSemantic proximity Read ↗

Putting the ‘HAT’ back on survival signalling: the promises and challenges of HDAC inhibition in the treatment of neurological conditionsSemantic proximity Read ↗

<i>In vitro</i> and <i>ex vivo</i> evaluation of second‐generation histone deacetylase inhibitors for the treatment of spinal muscular atrophySemantic proximity Read ↗

Drug Discovery for Histone Deacetylase Inhibition: Past, Present and Future of Zinc-Binding GroupsSemantic proximity Read ↗

Exifone is a Potent HDAC1 Activator with Neuroprotective Activity in Human Neuronal Models of NeurodegenerationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.