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Article

Metabotropic glutamate receptor 1 expression and its polymorphic variants associate with breast cancer phenotypes.

PloS one - 1 Jan 2013

Mehta Madhura S, Dolfi Sonia C, Bronfenbrener Roman, Bilal Erhan, Chen Chunxia, Moore Dirk, Lin Yong, Rahim Hussein, Aisner Seena, Kersellius Romona D, Teh Jessica, Chen Suzie, Toppmeyer Deborah L, Medina Dan J, Ganesan Shridar, Vazquez Alexei, Hirshfield Kim M

Abstract excerpt

Several epidemiological studies have suggested a link between melanoma and breast cancer. Metabotropic glutamate receptor 1 (GRM1), which is involved in many cellular processes including proliferation and differentiation, has been implicated in melanomagenesis, with ectopic expression of GRM1 causing malignant transformation of melanocytes. This study was undertaken to evaluate GRM1 expression and polymorphic...

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Source

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Identifiers

PMID: 23922822
DOI: 10.1371/journal.pone.0069851
PMCID: PMC3724883

Genes

GRM1

Provenance

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