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Article

Somatic mutation of GRIN2A in malignant melanoma results in loss of tumor suppressor activity via aberrant NMDAR complex formation.

The Journal of investigative dermatology - 1 Sept 2014

Prickett Todd D, Zerlanko Brad J, Hill Victoria K, Gartner Jared J, Qutob Nouar, Jiang Jiji, Simaan May, Wunderlich John, Gutkind J Silvio, Rosenberg Steven A, Samuels Yardena

Abstract excerpt

The ionotropic glutamate receptors (N-methyl-D-aspartate receptors (NMDARs)) are composed of large complexes of multi-protein subunits creating ion channels in the cell plasma membranes that allow for influx or efflux of mono- or divalent cations (e.g., Ca(2+)) important for synaptic transmissions, cellular migration, and survival. Recently, we discovered the high prevalence of somatic mutations within one of the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24739903
DOI: 10.1038/jid.2014.190
PMCID: PMC4134353

Genes

GRIN1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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