Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Metabotropic glutamate receptor-1: a potential therapeutic target for the treatment of breast cancer.

Breast cancer research and treatment - 1 Apr 2012

Speyer Cecilia L, Smith Jennifer S, Banda Malathi, DeVries John A, Mekani Tassia, Gorski David H

Abstract excerpt

Metabotropic glutamate receptors are G-protein-coupled receptors normally expressed in the central nervous system where they mediate neuronal excitability, synaptic plasticity, and feedback inhibition of neurotransmitter release. However, recent data suggest that these receptors are also expressed and functional in some cancers, most notably melanoma. We detected the expression of metabotropic glutamate...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Excitatory Amino Acid Agonists
Share to Excitatory Amino Acid Antagonists

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Injections, Intraperitoneal

Share to Mice, Nude

Share to Naphthalenes

Share to Receptors, Metabotropic Glutamate

Share to Tumor Burden

Share to Xenograft Model Antitumor Assays

Source

Open in PubMed Open full text

Identifiers

PMID: 21681448
DOI: 10.1007/s10549-011-1624-x
PMCID: PMC3898178

Genes

GRM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Metabotropic glutamate receptor-1: a potential therapeutic target for the treatment of breast cancer.PMID 21681448Read ↗

Metabotropic Glutamate Receptor-1 Contributes to Progression in Triple Negative Breast CancerSemantic proximity Read ↗

Metabotropic Glutamate Receptor-1 as a Novel Target for the Antiangiogenic Treatment of Breast CancerSemantic proximity Read ↗

A phase 0 trial of riluzole in patients with resectable stage III and IV melanoma.Semantic proximity Read ↗

Glutamatergic pathway targeting in melanoma: single-agent and combinatorial therapies.Semantic proximity Read ↗

Somatic mutations in GRM1 in cancer alter metabotropic glutamate receptor 1 intracellular localization and signaling.Semantic proximity Read ↗

Metabotropic glutamate receptor 1 expression and its polymorphic variants associate with breast cancer phenotypes.Semantic proximity Read ↗

Metabotropic glutamate receptor 1 (Grm1) is an oncogene in epithelial cells.Semantic proximity Read ↗

Inhibition of Metabotropic Glutamate Receptor III facilitates sensitization to alkylating chemotherapeutics in GlioblastomaSemantic proximity Read ↗

Involvement of metabotropic glutamate receptor 1, a G protein coupled receptor, in melanoma development.Semantic proximity Read ↗

RNAi Screening in Primary Human Breast Biopsies Identifies Mitochondrial Glutamate Flux as A Metabolic Vulnerability in Locally Advanced Breast CancerSemantic proximity Read ↗

NMDA Receptor-Mediated Signaling Pathways Enhance Radiation Resistance, Survival and Migration in Glioblastoma Cells—A Potential Target for Adjuvant RadiotherapySemantic proximity Read ↗

Glutamate receptors: emerging players in melanomagenesis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.