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Article

Metabotropic glutamate receptor 1 (Grm1) is an oncogene in epithelial cells.

Oncogene - 12 Sept 2013

Martino J J, Wall B A, Mastrantoni E, Wilimczyk B J, La Cava S N, Degenhardt K, White E, Chen S

Abstract excerpt

Non-neuronal expression of components of the glutamatergic system has been increasingly observed, and our laboratory previously had demonstrated the etiological role of ectopically expressed metabotropic glutamate receptor 1 (Grm1/mGluR1) in mouse models of melanoma. We hypothesize that inappropriate glutamatergic signaling in other cell types can dysregulate growth leading to transformation and tumorigenesis. As...

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Source

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Identifiers

PMID: 23085756
DOI: 10.1038/onc.2012.471
PMCID: PMC3910169

Genes

GRM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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