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Screening a library of temperature-sensitive mutants to identify secretion factors in Staphylococcus aureus

16 Jan 2025

Abstract excerpt

ABSTRACT Protein secretion is an essential cell process in bacteria, required for cell envelope biogenesis, export of virulence factors, and acquisition of nutrients, among other important functions. In the Sec secretion pathway, signal peptide-bearing precursors are recognized by the SecA ATPase and pushed across the membrane through a translocon channel made of the proteins SecY, SecE, and SecG. The Sec pathway...

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PMID: 39817767
DOI: 10.1128/jb.00433-24

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