Article
Elfn1 recruits presynaptic mGluR7 in trans and its loss results in seizures.
Nature communications - 22 Jul 2014
Tomioka Naoko H, Yasuda Hiroki, Miyamoto Hiroyuki, Hatayama Minoru, Morimura Naoko, Matsumoto Yoshifumi, Suzuki Toshimitsu, Odagawa Maya, Odaka Yuri S, Iwayama Yoshimi, Won Um Ji, Ko Jaewon, Inoue Yushi, Kaneko Sunao, Hirose Shinichi, Yamada Kazuyuki, Yoshikawa Takeo, Yamakawa Kazuhiro, Aruga Jun
Abstract excerpt
GABAergic interneurons are highly heterogeneous, and much is unknown about the specification and functional roles of their neural circuits. Here we show that a transinteraction of Elfn1 and mGluR7 controls targeted interneuron synapse development and that loss of Elfn1 results in hyperactivity and sensory-triggered epileptic seizures in mice. Elfn1 protein increases during postnatal development and localizes to...
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