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Article

Interaction between the MTHFR C677T polymorphism and traumatic childhood events predicts depression.

Translational psychiatry - 30 Jul 2013

Lok A, Bockting C L H, Koeter M W J, Snieder H, Assies J, Mocking R J T, Vinkers C H, Kahn R S, Boks M P, Schene A H

Abstract excerpt

Childhood trauma is associated with the onset and recurrence of major depressive disorder (MDD). The thermolabile T variant of the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism (rs1801133) is associated with a limited (oxidative) stress defense. Therefore, C677T MTHFR could be a...

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Source

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Identifiers

PMID: 23900311
DOI: 10.1038/tp.2013.60
PMCID: PMC3731792

Genes

MTHFR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23900311-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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