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Article

Genetic predisposition to advanced biological ageing increases risk for childhood-onset recurrent major depressive disorder in a large UK sample.

Journal of affective disorders - 15 Apr 2017

Michalek Julia E, Kepa Agnieszka, Vincent John, Frissa Souci, Goodwin Laura, Hotopf Matthew, Hatch Stephani L, Breen Gerome, Powell Timothy R

Abstract excerpt

BACKGROUND: Previous studies have revealed increased biological ageing amongst major depressive disorder (MDD) patients, as assayed by shorter leukocyte telomere lengths (TL). Stressors such as childhood maltreatment are more common amongst MDD patients, and it has been suggested that this might contribute to shorter TL present amongst patients. However, to our knowledge, no study has yet tested for reverse...

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Identifiers

PMID: 28233563
DOI: 10.1016/j.jad.2017.01.017
PMCID: PMC6191533

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