Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Drosophila fragile X protein, DFXR, regulates neuronal morphology and function in the brain.

Neuron - 13 Jun 2002

Morales Joannella, Hiesinger P Robin, Schroeder Andrew J, Kume Kazuhiko, Verstreken Patrik, Jackson F Rob, Nelson David L, Hassan Bassem A

Abstract excerpt

Mental retardation is a pervasive societal problem, 25 times more common than blindness for example. Fragile X syndrome, the most common form of inherited mental retardation, is caused by mutations in the FMR1 gene. Fragile X patients display neurite morphology defects in the brain, suggesting that this may be the basis of their mental retardation. Drosophila contains a single homolog of FMR1, dfxr (also called...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Circadian Rhythm
Share to Drosophila Proteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Fragile X Mental Retardation Protein

Share to Fragile X Syndrome

Share to Motor Activity

Share to Neuroglia

Share to Neurons

Share to RNA-Binding Proteins

Source

Identifiers

PMID: 12086643
DOI: 10.1016/s0896-6273(02)00731-6

Genes

FMR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Drosophila fragile X protein, DFXR, regulates neuronal morphology and function in the brain.PMID 12086643Read ↗

Fragile X mental retardation protein has a unique, evolutionarily conserved neuronal function not shared with FXR1P or FXR2P.Semantic proximity Read ↗

Control of dendritic development by the Drosophila fragile X-related gene involves the small GTPase Rac1.Semantic proximity Read ↗

Understanding fragile X syndrome: insights from animal models.Semantic proximity Read ↗

Integrative analysis identifies key molecular signatures underlying neurodevelopmental deficits in fragile X syndromeSemantic proximity Read ↗

Molecular and cellular aspects of mental retardation in the Fragile X syndrome: from gene mutation/s to spine dysmorphogenesis.Semantic proximity Read ↗

The RNA-binding protein fragile X-related 1 regulates somite formation in Xenopus laevis.Semantic proximity Read ↗

Defective neuronal development in the mushroom bodies of Drosophila fragile X mental retardation 1 mutants.Semantic proximity Read ↗

Mutational analysis establishes a critical role for the N terminus of fragile X mental retardation protein FMRP.Semantic proximity Read ↗

Drosophila lacking dfmr1 activity show defects in circadian output and fail to maintain courtship interest.Semantic proximity Read ↗

Lessons from fragile X regarding neurobiology, autism, and neurodegeneration.Semantic proximity Read ↗

Argonaute2 suppresses Drosophila fragile X expression preventing neurogenesis and oogenesis defects.Semantic proximity Read ↗

The FXG: A Presynaptic Fragile X Granule Expressed in a Subset of Developing Brain CircuitsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.