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Article

Polyglutamine domain flexibility mediates the proximity between flanking sequences in huntingtin.

Proceedings of the National Academy of Sciences of the United States of America - 3 Sept 2013

Caron Nicholas Stephane, Desmond Carly Robyn, Xia Jianrun, Truant Ray

Abstract excerpt

Huntington disease (HD) is a neurodegenerative disorder caused by a CAG expansion within the huntingtin gene that encodes a polymorphic glutamine tract at the amino terminus of the huntingtin protein. HD is one of nine polyglutamine expansion diseases. The clinical threshold of polyglutamine expansion for HD is near 37 repeats, but the mechanism of this pathogenic length is poorly understood. Using Förster...

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Identifiers

PMID: 23898200
DOI: 10.1073/pnas.1301342110
PMCID: PMC3767516

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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