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Article

Polyglutamine- and temperature-dependent conformational rigidity in mutant huntingtin revealed by immunoassays and circular dichroism spectroscopy.

PloS one - 1 Jan 2014

Fodale Valentina, Kegulian Natalie C, Verani Margherita, Cariulo Cristina, Azzollini Lucia, Petricca Lara, Daldin Manuel, Boggio Roberto, Padova Alessandro, Kuhn Rainer, Pacifici Robert, Macdonald Douglas, Schoenfeld Ryan C, Park Hyunsun, Isas J Mario, Langen Ralf, Weiss Andreas, Caricasole Andrea

Abstract excerpt

BACKGROUND: In Huntington's disease, expansion of a CAG triplet repeat occurs in exon 1 of the huntingtin gene (HTT), resulting in a protein bearing>35 polyglutamine residues whose N-terminal fragments display a high propensity to misfold and aggregate. Recent data demonstrate that polyglutamine expansion results in conformational changes in the huntingtin protein (HTT), which likely influence its biological and...

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Source

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Identifiers

PMID: 25464275
DOI: 10.1371/journal.pone.0112262
PMCID: PMC4251833

Genes

HTT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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