Article
The developmental and genetic basis of 'clubfoot' in the peroneal muscular atrophy mutant mouse.
Development (Cambridge, England) - 8 Feb 2018
Collinson J Martin, Lindström Nils O, Neves Carlos, Wallace Karen, Meharg Caroline, Charles Rebecca H, Ross Zoe K, Fraser Amy M, Mbogo Ivan, Oras Kadri, Nakamoto Masaru, Barker Simon, Duce Suzanne, Miedzybrodzka Zosia, Vargesson Neil
Abstract excerpt
Genetic factors underlying the human limb abnormality congenital talipes equinovarus ('clubfoot') remain incompletely understood. The spontaneous autosomal recessive mouse 'peroneal muscular atrophy' mutant (PMA) is a faithful morphological model of human clubfoot. In PMA mice, the dorsal (peroneal) branches of the sciatic nerves are absent. In this study, the primary developmental defect was identified as a...
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