Article
Maternal loss of miRNAs leads to increased variance in primordial germ cell numbers in Drosophila melanogaster.
G3 (Bethesda, Md.) - 4 Sept 2013
Kugler Jan-Michael, Chen Ya-Wen, Weng Ruifen, Cohen Stephen M
Abstract excerpt
MicroRNAs (miRNAs) are posttranscriptional regulators of gene expression that may act as buffering agents to stabilize gene-regulatory networks. Here, we identify two miRNAs that are maternally required for normal embryonic primordial germ cell development in Drosophila melanogaster. Embryos derived from miR-969 and miR-9c mutant mothers had, on average, reduced germ cell numbers. Intriguingly, this reduction...
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