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Article

<i>Lin28a</i> Regulates Germ Cell Pool Size and Fertility

4 Feb 2013

Abstract excerpt

Overexpression of LIN28A is associated with human germ cell tumors and promotes primordial germ cell (PGC) development from embryonic stem cells in vitro and in chimeric mice. Knockdown of Lin28a inhibits PGC development in vitro, but how constitutional Lin28a deficiency affects the mammalian reproductive system in vivo remains unknown. Here, we generated Lin28a knockout (KO) mice and found that Lin28a deficiency...

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PMID: 23378032
DOI: 10.1002/stem.1343

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