Article
Genetic circuitry controlling Drosophila female germline overgrowth.
Developmental biology - 1 Nov 2024
Zhang Qian, Li Le, Zhang Qi, Zhang Yang, Yan Lizhong, Wang Yanfang, Wang Yuejia, Zhao Shaowei
Abstract excerpt
Germ cells mutant for bam or bgcn are locked in a germline stem cell (GSC)-like state, leading to tumor-like overgrowth in Drosophila ovaries. Our previous studies have demonstrated that germline overgrowth in bam mutants can be suppressed by defects in the miRNA pathway but enhanced by a null mutation in hippo. However, the genetic epistasis between the miRNA and Hippo pathways still remains unknown. Here, we...
Topics
- Animals
- Female
- Drosophila Proteins
- MicroRNAs
- Germ Cells
- Ovary
- YAP-Signaling Proteins
- Drosophila melanogaster
- Protein Serine-Threonine Kinases
- Intracellular Signaling Peptides and Proteins
- Signal Transduction