Article
Highly variable recessive lethal or nearly lethal mutation rates during germ-line development of male Drosophila melanogaster.
Proceedings of the National Academy of Sciences of the United States of America - 20 Sept 2011
Gao Jian-Jun, Pan Xue-Rong, Hu Jing, Ma Li, Wu Jian-Min, Shao Ye-Lin, Barton Sara A, Woodruff Ronny C, Zhang Ya-Ping, Fu Yun-Xin
Abstract excerpt
Each cell of higher organism adults is derived from a fertilized egg through a series of divisions, during which mutations can occur. Both the rate and timing of mutations can have profound impacts on both the individual and the population, because mutations that occur at early cell divisions will affect more tissues and are more likely to be transferred to the next generation. Using large-scale multigeneration...
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