Article
In papillary thyroid carcinoma, TIMP-1 expression correlates with BRAF (V600E) mutation status and together with hypoxia-related proteins predicts aggressive behavior.
Virchows Archiv : an international journal of pathology - 1 Sept 2013
Ilie Marius I, Lassalle Sandra, Long-Mira Elodie, Hofman Véronique, Zangari Joséphine, Bénaim Gilles, Bozec Alexandre, Guevara Nicolas, Haudebourg Juliette, Birtwisle-Peyrottes Isabelle, Santini José, Brest Patrick, Hofman Paul
Abstract excerpt
BRAF (V600E) causes upregulation of tissue inhibitor of metalloproteinase-1 (TIMP-1), which promotes cell invasion in papillary thyroid carcinoma (PTC). Hypoxia-inducible factor-1α (HIF- α) is regulated by hypoxia and also by the BRAF-mediated signaling pathway in PTC. We assessed the association of expression of TIMP-1, HIF-1α, and hypoxia-inducible carbonic anhydrase IX (CAIX) and XII (CAXII) with clinical...
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