Article
Expression of hypoxia-associated proteins in sporadic medullary thyroid cancer is associated with desmoplastic stroma reaction and lymph node metastasis and may indicate somatic mutations in the VHL gene.
The Journal of pathology - 1 Sept 2011
Koperek Oskar, Bergner Oliver, Pichlhöfer Bettina, Oberndorfer Felicitas, Hainfellner Johannes A, Kaserer Klaus, Horvat Reinhard, Harris Adrian L, Niederle Bruno, Birner Peter
Abstract excerpt
Medullary thyroid carcinomas (MTCs) are mostly aggressive but slowly growing malignant tumours that metastasize early to loco-regional lymph nodes. Desmoplastic stroma reaction is a strong risk factor associated with lymph node metastases. We evaluated immunohistochemically the expression of two hypoxia-associated proteins, carbonic anhydrase IX (CAIX) and hypoxia-induced factor 1α (HIF1α), and ki-67,...
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