Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

TIMP1 promotes thyroid cancer cell progression through macrophage phenotypic polarization via the PI3K/AKT signaling pathway

9 Aug 2024

Abstract excerpt

Increasing evidence suggests that tissue inhibitor of metalloproteinase 1 (TIMP1) played a pivotal role in immune regulation. Our study focused on examining the expression and function of TIMP1 in humans, particularly in its regulation of tumor-associated macrophages (TAMs) in papillary thyroid carcinoma (PTC). We observed an upregulation of TIMP1 in 16 different types of malignancies, including thyroid cancer....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Ferroptosis and cancer prognosis
Share to Galectins and Cancer Biology
Share to Protease and Inhibitor Mechanisms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 39128817
DOI: 10.1016/j.ygeno.2024.110914

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

TIMP1 promotes thyroid cancer cell progression through macrophage phenotypic polarization via the PI3K/AKT signaling pathwayPMID 39128817Read ↗

MMP1 acts as a potential regulator of tumor progression and dedifferentiation in papillary thyroid cancerSemantic proximity Read ↗

TIMP2 is associated with prognosis and immune infiltrates of gastric and colon cancerSemantic proximity Read ↗

Knockdown of KDM1A suppresses tumour migration and invasion by epigenetically regulating the TIMP1/MMP9 pathway in papillary thyroid cancerSemantic proximity Read ↗

A Comprehensive Bioinformatics Analysis of TIMP2 in Multiple MalignanciesSemantic proximity Read ↗

Trop2 enhances invasion of thyroid cancer by inducing MMP2 through ERK and JNK pathwaysSemantic proximity Read ↗

The inhibitory effect of M2 macrophage-derived exosomes on gefitinib resistant lung adenocarcinoma cells through the MIF/TIMP1/CD74 axisSemantic proximity Read ↗

TGF-β induces M2-like macrophage polarization via SNAIL-mediated suppression of a pro-inflammatory phenotype.Semantic proximity Read ↗

TFF1 antagonizes TIMP‐1 mediated proliferative functions in gastric cancerSemantic proximity Read ↗

LAMA1 Promotes Tumor-Associated Macrophages Polarization Towards the M2 Phenotype and Induces Colorectal Cancer.Semantic proximity Read ↗

Higher levels of TIMP-1 expression are associated with a poor prognosis in triple-negative breast cancerSemantic proximity Read ↗

Matrix Metalloproteinases and the ThyroidSemantic proximity Read ↗

The Expression of Transcription Factors is Different in Papillary Thyroid Cancer Cells during TNF - α induced EMTSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.