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Article

Distinguishing functional amino acid covariation from background linkage disequilibrium in HIV protease and reverse transcriptase.

PloS one - 29 Aug 2007

Wang Qi, Lee Christopher

Abstract excerpt

Correlated amino acid mutation analysis has been widely used to infer functional interactions between different sites in a protein. However, this analysis can be confounded by important phylogenetic effects broadly classifiable as background linkage disequilibrium (BLD). We have systematically separated the covariation induced by selective interactions between amino acids from background LD, using synonymous (S)...

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Share to Amino Acid Sequence
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 17726544
DOI: 10.1371/journal.pone.0000814
PMCID: PMC1950573

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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