Article
Testing a covariotide model of DNA substitution.
Molecular biology and evolution - 1 May 2002
Huelsenbeck John P
Abstract excerpt
The concomitantly variable codons hypothesis of DNA substitution argues that at any time only a fraction of the codons in a gene are capable of accepting a mutation. However, as mutations are fixed at some positions in a gene, the sites that are potentially variable also change because of changed functional constraints. This hypothesis has been termed the "covarion" hypothesis or when the model is applied to...
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