Article
GATA: a graphic alignment tool for comparative sequence analysis.
BMC bioinformatics - 17 Jan 2005
Nix David A, Eisen Michael B
Abstract excerpt
BACKGROUND: Several problems exist with current methods used to align DNA sequences for comparative sequence analysis. Most dynamic programming algorithms assume that conserved sequence elements are collinear. This assumption appears valid when comparing orthologous protein coding sequences. Functional constraints on proteins provide strong selective pressure against sequence inversions, and minimize sequence...
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