Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Human cytosolic extracts stabilize the HIV-1 core.

Journal of virology - 1 Oct 2013

Fricke Thomas, Brandariz-Nuñez Alberto, Wang Xiaozhao, Smith Amos B, Diaz-Griffero Felipe

Abstract excerpt

The stability of the HIV-1 core in the cytoplasm is crucial for productive HIV-1 infection. Mutations that stabilize or destabilize the core showed defects on HIV-1 reverse transcription and infection. We developed a novel and simple assay to measure the stability of in vitro-assembled HIV-1 CA-NC complexes. The assay allowed us to demonstrate that cytosolic extracts strongly stabilize the HIV-1 core....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Capsid
Share to Cyclosporine
Share to Cytosol

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to gag Gene Products, Human Immunodeficiency Virus

Share to Immunosuppressive Agents

Share to Nucleocapsid

Share to Virion

Share to Virus Assembly

Source

Open in PubMed Open full text

Identifiers

PMID: 23885082
DOI: 10.1128/JVI.01705-13
PMCID: PMC3807412

Genes

CPSF6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Human cytosolic extracts stabilize the HIV-1 core.PMID 23885082Read ↗

Binding of host factors to stabilized HIV-1 capsid tubes.Semantic proximity Read ↗

Covalent anti-HIV compound that induces HIV-1 capsid multimerization and degradation decomposes the viral coreSemantic proximity Read ↗

Formation of a Human Immunodeficiency Virus Type 1 Core of Optimal Stability Is Crucial for Viral ReplicationSemantic proximity Read ↗

Inhibitors of the HIV-1 capsid, a target of opportunitySemantic proximity Read ↗

Ciclopirox inhibits SARS-CoV-2 replication by promoting the degradation of the nucleocapsid proteinSemantic proximity Read ↗

A Carboxy-Terminally Truncated Human CPSF6 Lacking Residues Encoded by Exon 6 Inhibits HIV-1 cDNA Synthesis and Promotes Capsid DisassemblySemantic proximity Read ↗

The primary mechanism for highly potent inhibition of HIV-1 maturation by lenacapavirSemantic proximity Read ↗

HIV-1 capsid protein and cyclophilin a as new targets for anti-AIDS therapeutic agents.Semantic proximity Read ↗

Dissecting the unique self-assembly landscape of the HIV-2 capsid proteinSemantic proximity Read ↗

Supercharged Assembly: A Broad-Spectrum Mechanism of Action for Drugs that Undermine Controlled HIV-1 Viral Capsid FormationSemantic proximity Read ↗

A trimer of dimers is the basic building block for human immunodeficiency virus-1 capsid assembly.Semantic proximity Read ↗

Identification of Capsid Mutations That Alter the Rate of HIV-1 Uncoating in Infected CellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.