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Ciclopirox inhibits SARS-CoV-2 replication by promoting the degradation of the nucleocapsid protein

12 Mar 2024

Abstract excerpt

The nucleocapsid protein (NP) plays a crucial role in SARS-CoV-2 replication and is the most abundant structural protein with a long half-life. Despite its vital role in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) assembly and host inflammatory response, it remains an unexplored target for drug development. In this study, we identified a small-molecule compound (ciclopirox) that promotes NP...

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PMID: 38828154
DOI: 10.1016/j.apsb.2024.03.009

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