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Article

Dimeric Rhodopsin R135L Mutant-Transducin-like Complex Sheds Light on Retinitis Pigmentosa Misfunctions.

The journal of physical chemistry. B - 2 Dec 2021

Guérin Diego M A, Digilio Ayelen, Branda María Marta

Abstract excerpt

Rhodopsin (RHO) is a light-sensitive pigment in the retina and the main prototypical protein of the G-protein-coupled receptor (GCPR) family. After receiving a light stimulus, RHO and its cofactor retinylidene undergo a series of structural changes that initiate an intricate transduction mechanism. Along with RHO, other partner proteins play key roles in the signaling pathway. These include transducin, a GTPase,...

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PMID: 34793169
DOI: 10.1021/acs.jpcb.1c06348

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