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Article

Conformational perturbation, allosteric modulation of cellular signaling pathways, and disease in P23H rhodopsin.

Scientific reports - 14 Feb 2020

Woods Kristina N, Pfeffer Jürgen

Abstract excerpt

In this investigation we use THz spectroscopy and MD simulation to study the functional dynamics and conformational stability of P23H rhodopsin. The P23H mutation of rod opsin is the most common cause of human binding autosomal dominant retinitis pigmentosa (ADRP), but the precise mechanism by which this mutation leads to photoreceptor cell degeneration has not yet been elucidated. Our measurements confirm...

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Identifiers

PMID: 32060349
DOI: 10.1038/s41598-020-59583-2
PMCID: PMC7021821

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