Article
β4GalT6 is involved in the synthesis of lactosylceramide with less intensity than β4GalT5.
Glycobiology - 1 Oct 2013
Tokuda Noriyo, Numata Shinichiro, Li Xiaojin, Nomura Tomoko, Takizawa Minoru, Kondo Yuji, Yamashita Yoriko, Hashimoto Noboru, Kiyono Tohru, Urano Takeshi, Furukawa Keiko, Furukawa Koichi
Abstract excerpt
Glycosphingolipids are expressed on the cell membrane and act as important factors in various events that occur across the plasma membrane. Lactosylceramide (LacCer) is synthesized from glucosylceramide and is a common precursor of various glycosphingolipids existing in whole body. Based on the enzyme purification, β1,4-galactosyltransferase 6 (B4galt6) cDNA was isolated as a LacCer synthase-coding gene in the...
Topics
- Animals
- Brain
- Cell Line
- Galactosyltransferases
- Lactosylceramides
- Mice
- Mice, Inbred C57BL
- Mice, Knockout
- Phenotype