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Article

Neuronal expression of GalNAc transferase is sufficient to prevent the age-related neurodegenerative phenotype of complex ganglioside-deficient mice.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 15 Jan 2014

Yao Denggao, McGonigal Rhona, Barrie Jennifer A, Cappell Joanna, Cunningham Madeleine E, Meehan Gavin R, Fewou Simon N, Edgar Julia M, Rowan Edward, Ohmi Yuhsuke, Furukawa Keiko, Furukawa Koichi, Brophy Peter J, Willison Hugh J

Abstract excerpt

Gangliosides are widely expressed sialylated glycosphingolipids with multifunctional properties in different cell types and organs. In the nervous system, they are highly enriched in both glial and neuronal membranes. Mice lacking complex gangliosides attributable to targeted ablation of the B4galnt1 gene that encodes β-1,4-N-acetylegalactosaminyltransferase 1 (GalNAc-transferase; GalNAcT(-/-)) develop normally...

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Identifiers

PMID: 24431446
DOI: 10.1523/JNEUROSCI.3996-13.2014
PMCID: PMC3891965

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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