Article
Multiple phenotypic changes in mice after knockout of the B3gnt5 gene, encoding Lc3 synthase--a key enzyme in lacto-neolacto ganglioside synthesis.
BMC developmental biology - 18 Nov 2010
Kuan Chien-Tsun, Chang Jinli, Mansson Jan-Eric, Li Jianjun, Pegram Charles, Fredman Pam, McLendon Roger E, Bigner Darell D
Abstract excerpt
BACKGROUND: Ganglioside biosynthesis occurs through a multi-enzymatic pathway which at the lactosylceramide step is branched into several biosynthetic series. Lc3 synthase utilizes a variety of galactose-terminated glycolipids as acceptors by establishing a glycosidic bond in the beta-1,3-linkage to GlcNaAc to extend the lacto- and neolacto-series gangliosides. In order to examine the lacto-series ganglioside...
Topics
- Alopecia
- Amino Acid Sequence
- Animals
- B-Lymphocytes
- Base Sequence
- Carbohydrate Sequence
- Embryo, Mammalian
- Female
- Gangliosides
- Immunophenotyping
- Isoenzymes