Article
Myelination in the absence of galactocerebroside and sulfatide: normal structure with abnormal function and regional instability.
Cell - 26 Jul 1996
Coetzee T, Fujita N, Dupree J, Shi R, Blight A, Suzuki K, Suzuki K, Popko B
Abstract excerpt
The vertebrate nervous system is characterized by ensheathment of axons with myelin, a multilamellar membrane greatly enriched in the galactolipid galactocerebroside (GalC) and its sulfated derivative sulfatide. We have generated mice lacking the enzyme UDP-galactose:ceramide galactosyltransferas...
Topics
- Animals
- Brain Chemistry
- Electrophysiology
- Fatty Acids
- Female
- Galactosylceramides
- Galactosyltransferases
- Lipid Metabolism
- Mice
- Mice, Knockout
- Microscopy, Electron
- Mutagenesis
- Myelin Sheath
- Nerve Fibers, Myelinated
- Neural Conduction
- Optic Nerve
- Phenotype
- Sciatic Nerve