Article
CPT-11 as a second-line treatment for patients with advanced/metastatic gastric cancer who failed S-1 (CCOG0702).
Cancer chemotherapy and pharmacology - 1 Sept 2013
Mochizuki Yoshinari, Ohashi Norifumi, Kojima Hiroshi, Ishigure Kiyoshi, Kinoshita Takashi, Eguchi Takehiko, Fujitake Shinichi, Ito Seiji, Fujiwara Michitaka, Kodera Yasuhiro
Abstract excerpt
BACKGROUND: In Japan, CPT-11 is often used to treat unresectable gastric cancer in the second-line setting. However, evidence regarding benefit of second-line chemotherapy remains sparse, especially after failing S-1. METHODS: A phase II study to evaluate the efficacy and safety of weekly administration of CPT-11 at a dose of 100 mg/m(2) after failing a S-1-containing first-line treatment was planned with...
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