Article

UGT1A1 28/37 Compound Heterozygosity Discovered via Reflex Sanger Sequencing: Successful Risk Management in Late-Line Gastric Cancer

2026-06-24

Abstract excerpt

<h4>Background: </h4> /Objectives: Irinotecan is a key late-line agent in metastatic gastric cancer, but its dose-limiting toxicities—severe neutropenia and diarrhea—are strongly influenced by UGT1A1 promoter polymorphisms. Commercial genotyping kits in Japan routinely interrogate only the common *6 and *28 alleles and may fail to resolve rarer TATA-box variants. We report a case in which an indeterminate commerci...

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Literature Corpus work: 05d823bc-3295-5c46-a32a-b467da967b51
DOI: 10.20944/preprints202606.1750.v1

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