Article
Analysis of UGT1A1*28 genotype and SN-38 pharmacokinetics for irinotecan-based chemotherapy in patients with advanced colorectal cancer: results from a multicenter, retrospective study in Shanghai.
Journal of cancer research and clinical oncology - 1 Sept 2013
Cai Xun, Cao Weiguo, Ding Honghua, Liu Tianshu, Zhou Xinli, Wang Mei, Zhong Ming, Zhao Ziyi, Xu Qing, Wang Liwei
Abstract excerpt
BACKGROUND: The UGT1A1*28 polymorphism, although closely linked with CPT-11-related adverse effects, cannot be used alone to guide individualized treatment decisions. However, CPT-11 dosage can be adjusted according to measured SN-38 pharmacokinetics. Our study is designed to investigate whether there is a relationship between SN-38 peak or valley concentrations and efficacy or adverse effects of CPT-11-based...
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