Article
Individual Irinotecan Therapy Under the Guidance of Pre-Treated UGT1A1*6 Genotyping in Gastric Cancer.
Technology in cancer research & treatment - 1 Jan 2000
Lv Huifang, Nie Caiyun, He Yunduan, Chen Beibei, Liu Yingjun, Zhang Junling, Chen Xiaobing
Abstract excerpt
Background: Severe delayed diarrhea and hematological toxicity limit the use of irinotecan. Uridine diphosphate glucuronosyltransferase 1A1 (UGT1A1) is a critical enzyme in irinotecan metabolism. The study aims to investigate the safety and efficacy of irinotecan under the guidance of the pre-treatment UGT1A1 genotype in the second-line treatment of gastric cancer. Methods: This study involved 110 patients....
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