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Determination of the UGT1A1 polymorphism as guidance for irinotecan dose adjustment in gastric cancer treated with second-line chemotherapy

2022-09-06

Abstract excerpt

<h4>Purpose: </h4> Uridine diphosphate glucuronosyltransferase 1A1 (UGT1A1) is a key enzyme in irinotecan metabolism. However, the relationship between UGT1A1 genotype and the safety and efficacy of irinotecan monotherapy in the treatment of Chinese advanced gastric cancer remains unclear. Methods A total of 110 patients were enrolled in this study. Intravenous irinotecan was administered every 3 weeks. Irinoteca...

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Literature Corpus work
5431d21c-f22c-5e88-a1d3-53d778d00cd5
DOI
10.21203/rs.3.rs-2025272/v1
Open publication

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