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Article

MTHFR polymorphism is associated with increased adverse events and poor clinical outcomes in gastric cancer patients with adjuvant S-1 chemotherapy.

Scientific reports - 18 Mar 2026

Kang Minsu, Kim Jin Won, Lee Ju Hyun, Kim Lyoung Hyo, Park Woochan, Kang So Hyun, Park Young Suk, Kim Ji-Won, Oh Hyeon Jeong, Ahn Sang-Hoon, Suh Yun-Suhk, Park Do Joong, Lee Hye Seung, Kim Hyung-Ho, Lee Keun-Wook

Abstract excerpt

S-1, an oral fluoropyrimidine composed of tegafur (a prodrug of 5-fluorouracil), gimeracil and oteracil, is widely used for gastric cancer. However, data on genetic variants influencing S-1 metabolism and their clinical impact remain limited. We enrolled 334 patients who underwent gastrectomy between July 2007 and May 2013, followed by adjuvant S-1 therapy. Genotyping of 46 SNPs in six genes (MTHFR, DPD, OPRT,...

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Source

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Identifiers

PMID: 41851142
DOI: 10.1038/s41598-026-38429-3
PMCID: PMC13139556

Genes

MTHFR
CYP2A6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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