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Article

Associations between UGT1A16/28 polymorphisms and irinotecan-induced severe toxicity in Chinese gastric or esophageal cancer patients.

Medical oncology (Northwood, London, England) - 1 Jan 2013

Gao Jing, Zhou Jun, Li Yanyan, Peng Zhi, Li Yilin, Wang Xicheng, Shen Lin

Abstract excerpt

The aim of this study was to investigate the associations between UDP-glucuronosyltransferase (UGT) 1A1 polymorphisms and irinotecan-induced toxicities in Chinese advanced gastric or esophageal cancer patients. The genotypes of UGT1A1*6 and UGT1A1*28 were analyzed by PCR amplification and Sanger sequencing in 42 gastric and 91 esophageal cancer patients receiving irinotecan-containing chemotherapy. The influences...

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PMID: 23783485
DOI: 10.1007/s12032-013-0630-8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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