Article
[Correlation between nUGT1A1 gene polymorphisms and adverse events of irinotecan plus S-1 for patients with recurrent or metastatic esophageal squamous cell carcinoma: a prospective, open-label, randomized controlled trial (ESWN 01)].
Zhonghua zhong liu za zhi [Chinese journal of oncology] - 23 Nov 2021
Wang X, Liu Y, Huang J X, Lu P, Ba Y, Wu L, Bai Y X, Zhang S, Feng J F, Cheng Y, Li J, Wen L, Yuan X L, Ma C W, Hu C H, Fan Q X, Xu B H, Huang J
Abstract excerpt
Objective: To investigate the correlation between UGT1A1 polymorphisms and the irinotecan plus S-1 regimen-induced toxicities in Chinese advanced esophageal squamous cell carcinoma (ESCC) patients. Methods: A total of 46 recurrent or metastatic ESCC patients selected from ESWN 01 trial were randomly assigned to irinotecan plus S-1 group [intravenous infusion of irinotecan (160 mg/m(2)) on day 1 and oral S-1...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.