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Sprouty genes regulate proliferation and survival of human embryonic stem cells

24 Jul 2013

Abstract excerpt

Sprouty (Spry) genes encode negative regulators of receptor tyrosine kinase (RTK) signaling, which plays important roles in human embryonic stem cells (hESCs). SPRY2 and SPRY4 are the two most highly expressed Sprouty family members in hESCs, suggesting that they may influence self-renewal. To test this hypothesis, we performed siRNA-mediated knock down (KD) studies. SPRY2 KD resulted in increased cell death and...

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PMID: 23880645
DOI: 10.1038/srep02277

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