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Article

FRS2α regulates Erk levels to control a self-renewal target Hes1 and proliferation of FGF-responsive neural stem/progenitor cells.

Stem cells (Dayton, Ohio) - 1 Sept 2010

Sato Takuya, Shimazaki Takuya, Naka Hayato, Fukami Shin-Ichi, Satoh Yasushi, Okano Hideyuki, Lax Irit, Schlessinger Joseph, Gotoh Noriko

Abstract excerpt

Fibroblast growth factor (FGF) is among the most common growth factors used in cultures to maintain self-renewal and proliferative capabilities of a variety of stem cells, including neural stem cells (NSCs). However, the molecular mechanisms underlying the control by FGF have remained elusive. Studies on mutant mice of FGF receptor substrate 2α (FRS2α), a central mediator for FGF signaling, combined with FRS2α...

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Identifiers

PMID: 20652960
DOI: 10.1002/stem.488
PMCID: PMC2996081

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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